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Transforming growth factor beta, pleiotropic regulator of hematopoietic stem cells: Potential physiological and clinical relevance

  1. Author:
    Ruscetti, F. W.
    Bartelmez, S. H.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, Leukocyte Biol Sect, Basic Res Lab, Ctr Canc Res, Bldg 567, Rm 251, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Leukocyte Biol Sect, Basic Res Lab, Ctr Canc Res, Frederick, MD 21702 USA. Univ Washington, Sch Publ Hlth, Dept Pathobiol, Seattle, WA 98195 USA. Ruscetti FW NCI, Frederick Canc Res & Dev Ctr, Leukocyte Biol Sect, Basic Res Lab, Ctr Canc Res, Bldg 567, Rm 251, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: International Journal of Hematology
    1. 74
    2. 1
    3. Pages: 18-25
  4. Type of Article: Article
  1. Abstract:

    Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodifferentiative or antidifferentiative. TGF-beta is the major regulator of stem cell quiescence and can act directly or indirectly through effects on the marrow microenvironment. In addition, paracrine and autocrine actions of TGF-beta have overlapping but distinct regulatory effects on hematopoietic stem/progenitor cells. Neutralization of autocrine TGF-beta has therapeutic potential. (C) 2001 The Japanese Society of Hematology.

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