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Complete characterization of the human ABC gene family

  1. Author:
    Dean, M.
    Allikmets, R.

  2. Author Address

    NCI, Human Genet Sect, Lab Genom Divers, Frederick, MD 21701 USA. NCI, Human Genet Sect, Lab Genom Divers, Frederick, MD 21701 USA. Columbia Univ, Dept Ophthalmol, New York, NY 10027 USA. Columbia Univ, Dept Pathol, New York, NY USA. Dean M NCI, Human Genet Sect, Lab Genom Divers, Frederick, MD 21701 USA.
    1. Year: 2001
  2. Journal: Journal of Bioenergetics and Biomembranes
    1. 33
    2. 6
    3. Pages: 475-479
  4. Type of Article: Article
  1. Abstract:

    The human ATP-binding cassette (ABC) transporters comprise a large family of membrane transport proteins and play a vital role in many cellular processes. The genes provide functions as diverse as peptide transport, cholesterol and sterol transport, bile acid, retinoid, and iron transport. In addition some ABC genes play a role as regulatory elements. Many ABC genes play a role in human genetic diseases, and several are critical drug transport proteins overexpressed in drug resistant cells. Analysis of the gene products allows the genes to be grouped into seven different subfamilies.

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