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Interleukin 1-Alpha Increases Serum Leptin Concentrations in Humans

  1. Author:
    Janik, J. E.
    Curti, B. D.
    Considine, R. V.
    Rager, H. C.
    Powers, G. C.
    Alvord, W. G.
    Smith, J. W.
    Gause, B. L.
    Kopp, W. C.

  2. Author Address

    Janik JE NCI MED BRANCH DIV CLIN SCI NIH BLDG 10 ROOM 12N226 9000 ROCKVILLE PIKE BETHESDA, MD 20892 USA INDIANA UNIV SCH MED INDIANAPOLIS, IN 46202 USA PROVIDENCE MED CTR EARLE CHILES RES INST PORTLAND, OR 97213 USA NCI FREDERICK CANC RES & DEV CTR SAIC FREDERICK DATA MANAGEMENT SERV INC FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Journal of Clinical Endocrinology & Metabolism
    1. 82
    2. 9
    3. Pages: 3084-3086
  4. Type of Article: Article
  1. Abstract:

    Leptin, the protein product of the ob gene, regulates appetite and body weight in animals. Endotoxin and cytokines, induced by endotoxin, interleukin (IL) 1 and tumor necrosis factor, increase expression of leptin in mice and hamsters. We measured serum leptin concentrations in patients with cancer before and after administration of recombinant human IL-1 alpha. Fourteen patients received IL-1 alpha at one of three dose levels (0.03, 0.1, or 0.3 mu g/kg.day) for 5 days. Serum leptin concentrations increased in all but two patients within 24 h after the first dose. The increase in leptin was correlated directly with IL-1 alpha dose (P = 0.0030). Despite continued administration of IL-1 alpha, serum leptin concentrations returned to pretreatment levels by day 5 of therapy. An increase in serum leptin concentrations may be one mechanism by which anorexia is induced by IL-1 alpha. However, tachyphylaxis of the leptin response suggests that other mechanisms also are involved. [References: 29]

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