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A radiation hybrid mapping panel for the rhesus macaque

  1. Author:
    Murphy, W. J.
    Page, J. E.
    Smith, C.
    Desrosiers, R. C.
    O'Brien, S. J.

  2. Author Address

    NCI, Lab Genome Divers, FCRCD, Bldg 560,Rm 11-10, Frederick, MD 21702 USA NCI, Lab Genome Divers, FCRCD, Frederick, MD 21702 USA Harvard Univ, Sch Med, New England Reg Primate Res Ctr, Southborough, MA 01772 USA Murphy WJ NCI, Lab Genome Divers, FCRCD, Bldg 560,Rm 11-10, Frederick, MD 21702 USA
    1. Year: 2001
  2. Journal: Journal of Heredity
    1. 92
    2. 6
    3. Pages: 516-519
  4. Type of Article: Article
  1. Abstract:

    The genomes of nonhuman primates have recently become highly visible candidates for full genome analysis, as they provide powerful models of human disease and a better understanding of the evolution of the human genome. We describe the creation of a 5000 rad radiation hybrid (RH) mapping panel for the rhesus macaque. Duplicate genotypes of 84 microsatellite and coding gene sequence tagged sites from six macaque chromosomes produced an estimated whole genome retention frequency of 0.33. To test the mapping ability of the panel, we constructed RH maps for macaque chromosomes 7 and 9 and compared them to orthologous locus orders in existing human and baboon maps derived from different methodologies. Concordant marker order between all three species maps suggests that the current panel represents a powerful mapping resource for generating high- density comparative maps of the rhesus macaque and other species genomes.

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