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Combined histiologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice

  1. Author:
    Morse, H. C.
    Qi, C. F.
    Chattopadhyay, S. K.
    Hori, M.
    Taddesse-Heath, L.
    Ozato, K.
    Hartley, J. W.
    Taylor, B. A.
    Ward, J. M.
    Jenkins, N. A.
    Copeland, N. G.
    Fredrickson, T. N.

  2. Author Address

    NIAID, Immunopathol Lab, NIH, Room 7-304, 7 Ctr Dr, Bethesda, MD 20892 USA. NIAID, Immunopathol Lab, NIH, Bethesda, MD 20892 USA. NICHHD, Lab Mol Growth Regulat, NIH, Bethesda, MD 20892 USA. Jackson Lab, Bar Harbor, ME 04609 USA. NCI, Vet & Tumor Pathol Sect, NIH, Frederick, MD 21702 USA. NCI, Mouse Canc Genet Program, NIH, Frederick, MD 21702 USA. Morse HC NIAID, Immunopathol Lab, NIH, Room 7-304, 7 Ctr Dr, Bethesda, MD 20892 USA.
    1. Year: 2001
  2. Journal: Leukemia Research
    1. 25
    2. 8
    3. Pages: 719-733
  4. Type of Article: Article
  1. Abstract:

    Hematopoietic neoplasms developing in AKXD recombinant inbred, NFS.V+ and ICSBP knockout mice were assessed using morphologic, cytologic and molecular criteria that relate these disorders to human lymphoma, and leukemia. Lymphoma types included precursor T-cell and B-cell lymphoblastic, small lymphocytic, splenic marginal zone, follicular, and diffuse large cell (DLCL). In addition to previously defined subtypes of DLCL composed of centroblasts or immunoblasts, two additional subtypes are defined here: lymphoblastic lymphoma like (LL) and lymphoma characterized by a histiocytic reaction (HS). DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements. Published by Elsevier Science Ltd.

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