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New nitrogenous constituents from the South African marine ascidian Pseudodistoma sp

  1. Author:
    Rashid, M. A.
    Gustafson, K. R.
    Cartner, L. K.
    Pannell, L. K.
    Boyd, M. R.

  2. Author Address

    NCI, Mol Target Drug Dev Program, Canc Res Ctr, Bldg 1052, Room 121, Frederick, MD 21702 USA. NCI, Mol Target Drug Dev Program, Canc Res Ctr, Frederick, MD 21702 USA. NIDDKD, Bioorgan Chem Lab, Bethesda, MD 20892 USA. SAIC Frederick, Intramural Res Support Program, Frederick, MD 21702 USA. Boyd MR NCI, Mol Target Drug Dev Program, Canc Res Ctr, Bldg 1052, Room 121, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Tetrahedron
    1. 57
    2. 27
    3. Pages: 5751-5755
  4. Type of Article: Article
  1. Abstract:

    Cytotoxicity-guided fractionation of an extract of the South African marine ascidian Pseudodistoma sp. provided pseudodistamine (1), a new bis alkyl amine, two new aliphatic amines 2 and 3, and a new P-carboline alkaloid 4. The structures of compounds 1-4 were elucidated by spectroscopic methods and by comparison with spectral data from structurally related compounds. The absolute stereochemistry of 1 was assigned by Mosher's eater analyses, while the stereochemistry of 2 and 3 was established by degradation and derivatization studies. Compound 2 demonstrated cytotoxic activity against four different human tumor cell lines, with an IC50 of approximately 6.0 mug/mL. Published by Elsevier Science Ltd.

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