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Effects of prolactin on hematopoiesis

  1. Author:
    Welniak, L. A.
    Richards, S. M.
    Murphy, W. J.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, IRSP, SAIC Frederick, Bldg 567, Rm 210, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, IRSP, SAIC Frederick, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, SAIC Frederick, Frederick, MD 21702 USA. Genzyme Corp, Framingham, MA 01701 USA. Murphy WJ NCI, Frederick Canc Res & Dev Ctr, IRSP, SAIC Frederick, Bldg 567, Rm 210, Frederick, MD 21702 USA.
    1. Year: 2001
  2. Journal: Lupus
    1. 10
    2. 10
    3. Pages: 700-705
  4. Type of Article: Review
  1. Abstract:

    The presence of extra-pituitary prolactin and its cognitive receptors in the hematopoietic microenvironment raises the question of whether prolactin plays a role in lympho- hematopoiesis and under what conditions. Current studies suggest that endogenous prolactin does not play a significant role under normal steady-state conditions. Rather, prolactin has been implicated as a 'stress hormone', functioning to restore hematopoietic homeostasis under conditions of dysregulation. The stress response of prolactin as well as its complex relationship with other hormones and factors has resulted in conflicting reports in the literature regarding prolactin's role in lympho-hematopoiesis. A review of this literature is provided as well as discussion of conditions under which lymphohematopoietic activity of prolactin may be evident.

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