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Invertebrate glutathione transferases conjugating 4- hydroxynonenal: CeGST 5.4 from Caenorhabditis elegans

  1. Author:
    Engle, M. R.
    Singh, S. P.
    Nanduri, B.
    Ji, X. H.
    Zimniak, P.

  2. Author Address

    John L McClellan Mem Vet Adm Med Ctr, 4300 W 7th St, Little Rock, AR 72205 USA. Univ Arkansas Med Sci, Dept Biochem & Mol Biol, Little Rock, AR 72205 USA. Univ Arkansas Med Sci, Dept Internal Med, Little Rock, AR 72205 USA. NCI, Biomol Struct Sect, Macromol Crystallog Lab, FCRDC, Frederick, MD 21702 USA. Zimniak P John L McClellan Mem Vet Adm Med Ctr, 4300 W 7th St, Little Rock, AR 72205 USA.
    1. Year: 2001
  2. Journal: Chemico-Biological Interactions
    1. 133
    2. 1-3, Special Issue
    3. Pages: 244-248
  4. Type of Article: Article
  1. Abstract:

    Formation of 4-hydroxyalkenals appears to be an obligatory consequence of aerobic metabolism, especially respiration. Mammals have evolved a special group of alpha -class GSTs with high catalytic activity towards 4-hydroxyalkenals, We now identified an invertebrate (Caenorhabditis elegans) GST with the same activity, named CeGST 5.4. The enzyme is closely related to the pi class of GSTs. This finding demonstrates that conjugation of 4-hydroxyalkenals is phylogenetically widespread and thus probably physiologically essential, at least in aerobes. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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