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Radiation quality and tissue-specific microenvironments following exposure to 1 GeV/amu Fe

  1. Author:
    Costes, S.
    Barcellos-Hoff, M. H.

  2. Author Address

    Costes S Natl Canc Inst, Ft Detrick,Bldg 538, Frederick, MD 21702 USA
    1. Year: 2002
  2. Book Title: Space Life Sciences: Biological Research and Space Radiation
  3. Series Title: Advances in Space Research
    1. 30, Issue 4
    2. Pages: 865-870
  5. Type of Work: Book Chapter
  1. Abstract:

    This paper summarizes quantitative in vivo laminin immunofluorescence analysis of mammary glands and skin epithelial structures from mice exposed to 1 GeV/amu Fe ions. Digital confocal microscopic images were quantified and linked to the rough "core-penumbra" Fe track physical description. Comparison to gamma-ray sparsely ionizing radiation suggested the core of the Fe track being responsible for a biological response only seen with energetic Fe particles. Conclusions for modeling in vivo responses to radiation were then implied. (C) 2002 COSPAR. Published by Elsevier Science Ltd. All rights reserved.

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