Skip NavigationSkip to Content
Return Return to Search Results

Design and synthesis of a beta-amino phosphotyrosyl mimetic suitably protected for peptide synthesis

  1. Author:
    Lee, K.
    Zhang, M. C.
    Yang, D. J.
    Burke, T. R.

  2. Author Address

    NCI, Med Chem Lab, Canc Res Ctr, NIH, Frederick, MD 21702 USA NCI, Med Chem Lab, Canc Res Ctr, NIH, Frederick, MD 21702 USA Univ Michigan, Dept Hematol Oncol, Ann Arbor, MI 48109 USA Burke TR NCI, Med Chem Lab, Canc Res Ctr, NIH, Frederick, MD 21702 USA
    1. Year: 2002
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 12
    2. 23
    3. Pages: 3399-3401
  4. Type of Article: Article
  1. Abstract:

    Mimetics of phosphotyrosine (pTyr) such as phosphonomethylphertylalanine (Pmp) have traditionally retained a-amino functionality. However, beta-amino acids represent isomeric variants, which may exhibit properties that are distinct from the parent. Reported herein is the first beta- amino pTyr mimetic (Pmp(beta)) bearing protection suitable for peptide synthesis. Preparation of Pmp(beta) was accomplished enantioselectively in 43% overall yield from commercially available 4-vinylbenzyl chloride. (C) 2002 Elsevier Science Ltd. All rights reserved.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel