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Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues

  1. Author:
    Tumanov, A. V.
    Kuprash, D. V.
    Lagarkova, M. A.
    Grivennikov, S. I.
    Abe, K.
    Shakhov, A. N.
    Drutskaya, L. N.
    Stewart, C. L.
    Chervonsky, A. V.
    Nedospasov, S. A.

  2. Author Address

    VA Engelhardt Mol Biol Inst, Lab Mol Immunol, Moscow 119991, Russia VA Engelhardt Mol Biol Inst, Lab Mol Immunol, Moscow 119991, Russia Belozersky Inst Physicochem Biol, Moscow 119991, Russia NCI, Basic Res Program, Sci Applicat Int Corp Frederick, Frederick, MD 21702 USA NCI, Mol Immunoregulat Lab, Canc & Dev Biol Lab, Ctr Canc Res, Frederick, MD 21702 USA Jackson Lab, Bar Harbor, ME 04609 USA Nedospasov SA VA Engelhardt Mol Biol Inst, Lab Mol Immunol, Moscow 119991, Russia
    1. Year: 2002
  2. Journal: Immunity
    1. 17
    2. 3
    3. Pages: 239-250
  4. Type of Article: Article
  1. Abstract:

    In order to definitively ascertain the functional contribution of lymphotoxin (LT) expressed by B cells, we produced mice with the LTbeta gene deleted from B cells (B-LTbeta KO mice). In contrast to systemic LTbeta deletion, in B-LTbeta KO mice only splenic microarchitecture was affected, while lymph nodes and Peyer's patches (PP) were normal, except for PP's reduced size. Even though B-LTbeta KO spleens retained a small number of follicular dendritic cells (FDC) which appeared to be dependent on LPbeta produced by T cells, IgG responses to sheep red blood cells were markedly reduced. Thus, the organogenic function of B-LTbeta is almost entirely restricted to spleen, where it supports the correct lymphoid architecture that is critical for an effective humoral immune response.

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