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New dimeric macrolide glycosides from the marine sponge Myriastra clavosa

  1. Author:
    Erickson, K. L.
    Gustafson, K. R.
    Pannell, L. K.
    Beutler, J. A.
    Boyd, M. R.

  2. Author Address

    NCI, Mol Targets Drug Discovery Program, Ctr Canc Res, Bldg 1052,Room 121, Frederick, MD 21701 USA NCI, Mol Targets Drug Discovery Program, Ctr Canc Res, Frederick, MD 21701 USA Gustafson KR NCI, Mol Targets Drug Discovery Program, Ctr Canc Res, Bldg 1052,Room 121, Frederick, MD 21701 USA
    1. Year: 2002
  2. Journal: Journal of Natural Products
    1. 65
    2. 9
    3. Pages: 1303-1306
  4. Type of Article: Article
  1. Abstract:

    Clavosolides A-D (1-4), dimeric macrolides incorporating cyclopropyl, tetrahydropyranyl, and glycosidic ring systems, were isolated from the cytotoxic extract of a Philippines collection of the marine sponge Myriastra clavosa. The structures of the clavosolides, which occurred as only trace metabolites, were elucidated through extensive NMR spectroscopic analyses. Clavosolides A (1) and B (2) were recently reported metabolites from M. clavosa, while the unsymmetrical dimers clavosolides C (3) and D (4) had new structures.

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