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Antitumor effects induced by dendritic cell-based immunotherapy against established pancreatic cancer in hamsters

  1. Author:
    Akiyama, Y.
    Maruyama, K.
    Nara, N.
    Hojo, T.
    Cheng, J. Y.
    Mori, T.
    Wiltrout, R. H.
    Yamaguchi, K.

  2. Author Address

    Natl Canc Ctr, Res Inst, Div Growth Factor, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan Natl Canc Ctr, Res Inst, Div Growth Factor, Chuo Ku, Tokyo 1040045, Japan Nara Med Univ, RI Ctr, Kashihara, Nara 6348521, Japan NCI, Frederick Canc Res & Dev Ctr, Expt Therapeut Sect, Expt Immunol Lab, Frederick, MD 21702 USA Akiyama Y Natl Canc Ctr, Res Inst, Div Growth Factor, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan
    1. Year: 2002
    2. Date: Oct 8
  2. Journal: Cancer Letters
    1. 184
    2. 1
    3. Pages: 37-47
  4. Type of Article: Article
  1. Abstract:

    Because the prognosis of patients with pancreatic cancer is very poor, development of a novel approach for treatment of this disease is vital. In the present study, we investigated the effect of dendritic cell (DC)-based immunotherapy against established syngeneic hamster pancreatic cancer named HPD1NR. Hamster enriched DCs were prepared from bone marrow (BM) by a culture for 7 days in the presence of mouse GM-CSF and mouse IL-4, and characterized by the expression of specific DC markers (DEC205, DC-SIGN) mRNA using in situ hybridization (ISH). DCs pulsed with tumor lysate and N-[1-(2,3- dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP) or DCs alone were injected s.c. weekly into HPDINR- bearing hamsters three times. Tumor growth was significantly inhibited by 82% in hamsters treated with tumor lysate and DOTAP-pulsed DCs when compared with the PBS vehicle-treated group. These findings suggest that DC-based immunotherapy may be a useful approach for the treatment of pancreatic cancers. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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  2. DOI: 10.1016/S0304-3835(02)00189-1
  3. PMID: 12104046

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