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Prospective study of hepatitis C viral infection as a risk factor for subsequent B-cell neoplasia

  1. Author:
    Rabkin, C. S.
    Tess, B. H.
    Christianson, R. E.
    Wright, W. E.
    Waters, D. J.
    Alter, H. J.
    van den Berg, B. J.

  2. Author Address

    NCI, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS-7026, Rockville, MD 20852 USA NCI, Div Canc Epidemiol & Genet, Rockville, MD 20852 USA Child Hlth & Dev Studies, Berkeley, CA USA Calif Dept Hlth Serv, Canc Surveillance Sect, Sacramento, CA USA Sci Applicat Int Corp, Frederick, MD USA NIH, Dept Transfus Med, Ctr Clin, Bethesda, MD USA Rabkin CS NCI, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS-7026, Rockville, MD 20852 USA
    1. Year: 2002
  2. Journal: Blood
    1. 99
    2. 11
    3. Pages: 4240-4242
  4. Type of Article: Article
  1. Abstract:

    Several case-control studies have found increased prevalence of hepatitis C virus (HCV) in patients with non-Hodgkin lymphoma (NHL) and other B-cell lympho-proliferative disorders. We examined whether HCV infection preceded the development of these neoplasms in a prospective cohort study of 48 420 individuals in northern California. Stored sera from 95 subjects with NHL (n = 57), multiple myeloma (n = 24), or Hodgkin disease (n = 14) diagnosed a mean of 21 years after phlebotomy were screened for antibodies to HCV as well as viral RNA, based on previous reports of antibody-negative viremia. Sera from 4 cases and one of 95 age-, sex-, and race-matched controls were repeatedly reactive by enzyme immunoassay, but none were confirmed by recombinant immunoblot assay; none of the case sera had HCV RNA by reverse transcription-polymerase chain reaction. Although acquisition In later life cannot be ruled out, these prospective data do not support a substantial role of chronic HCV Infection in the etiology of B-cell neoplasia. (C) 2002 by The American Society of Hematology.

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