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The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders

  1. Author:
    Klar, A. J. S.

  2. Author Address

    NCI, Gene Regulat & Chromosome Biol Lab, POB B,Ft Detrick,Bldg 539, Frederick, MD 21702 USA NCI, Gene Regulat & Chromosome Biol Lab, Frederick, MD 21702 USA Klar AJS NCI, Gene Regulat & Chromosome Biol Lab, POB B,Ft Detrick,Bldg 539, Frederick, MD 21702 USA
    1. Year: 2002
  2. Journal: Genetics
    1. 160
    2. 4
    3. Pages: 1745-1747
  4. Type of Article: Article
  1. Abstract:

    Genetics is assumed to cause susceptibility to psychosis, but no major locus has been identified. These disorders cosegregate with a chromosome 1:11 translocation in a Scottish pedigree where 50% of the carriers are diseased. A genetic model originally proposed to explain the basis of these illnesses predicts such an outcome.

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