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Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation

  1. Author:
    Zhu, J. F.
    Guo, L. Y.
    Min, B. K.
    Watson, C. J.
    Hu-Li, J.
    Young, H. A.
    Tsichlis, P. N.
    Paul, W. E.

  2. Author Address

    NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA NCI, Expt Immunol Lab, Frederick, MD 21701 USA Thomas Jefferson Univ, Dept Microbiol & Immunol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA Zhu JF NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA
    1. Year: 2002
  2. Journal: Immunity
    1. 16
    2. 5
    3. Pages: 733-744
  4. Type of Article: Article
  1. Abstract:

    IL-4 is important in Th2 differentiation and in cell expansion. Stat6 is necessary and sufficient for both functions. Although Gata3 is critical for Th2 polarization, it is not sufficient to mediate IL-4-driven cell expansion. We report that growth factor independent-1 (Gfi-1), a Stat6-dependent transcriptional repressor, strikingly increases Th2 cell expansion by promoting proliferation and preventing apoptosis. Cells infected with a Gfi-1 retrovirus show striking enhancement of IL-2-induced Stat5 phosphorylation and repression of p27(Kip-1) expression, suggesting a potential mechanism for the Gfi-1 growth effect. The synergy of Gfi-1 and Gata3 provides a mechanism through which IL-4 could selectively promote Th2 cell expansion.

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