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One-pot synthesis of benzo b furan and indole inhibitors of tubulin polymerization

  1. Author:
    Flynn, B. L.
    Hamel, E.
    Jung, M. K.

  2. Author Address

    Australian Natl Univ, Dept Chem, Canberra, ACT 0200, Australia Australian Natl Univ, Dept Chem, Canberra, ACT 0200, Australia NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,NIH, Frederick, MD 21702 USA NCI, Sci Applicat Int Corp, NIH, Frederick, MD 21702 USA Flynn BL Australian Natl Univ, Dept Chem, Canberra, ACT 0200, Australia
    1. Year: 2002
  2. Journal: Journal of Medicinal Chemistry
    1. 45
    2. 12
    3. Pages: 2670-2673
  4. Type of Article: Article
  1. Abstract:

    Benzo[b]furan and indole analogues of some recently identified benzo[b]thiophene inhibitors of tubulin polymerization have been prepared, and their biological activity has been assessed. Several very potent analogues were identified.

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