Skip NavigationSkip to Content
Return Return to Search Results

Cloning and embryonic expression analysis of the mouse Gbx1 gene

  1. Author:
    Waters, S. T.
    Wilson, C. P.
    Lewandoski, M.

  2. Author Address

    NCI, Lab Canc & Dev Biol, NIH, Frederick, MD 21702 USA NCI, Lab Canc & Dev Biol, NIH, Frederick, MD 21702 USA Lewandoski M NCI, Lab Canc & Dev Biol, NIH, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Gene Expression Patterns
    1. 3
    2. 3
    3. Pages: 313-317
  4. Type of Article: Article
  1. Abstract:

    We report the cloning of a cDNA encoding the complete mouse Gbx1 coding region as well as a comparative expression analysis of Gbx1 and Gbx2 during murine development. Gbx1 is expressed first during gastrulation and later in a dynamic pattern in the central nervous system, including rhombomeres 3 and 5, optic vesicles, and the medial ganglionic eminence. Gbx1 expression is not upregulated in Gbx2 null homozygotes. Therefore, the only regions of potential genetic redundancy are where Gbx1 and 2 are normally coexpressed: the primitive streak, regions of the ventricular zone of the neural tube and the medial ganglionic eminence. Finally, we demonstrate that neither Gbx1 nor Gbx2 require FGF8 for expression during gastrulation, contrary to previous published reports. (C) 2003 Elsevier Science B.V. All rights reserved.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel