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Comparison of virology and immunology in SHIV 89.6 proviral DNA and virus-inoculated rhesus macaques

  1. Author:
    Busch, M.
    Lu, D.
    Fritts, L.
    Lifson, J. D.
    Miller, C. J.
  2. Author Address

    Univ Calif Davis, CNPRC, 1 Shields Ave Davis, Davis, CA 95616 USA Univ Calif Davis, CNPRC, Davis, CA 95616 USA Univ Calif Davis, Ctr Comparat Med, Davis, CA 95616 USA NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, Retroviral Pathogenesis Lab,AIDS Vaccine Program, Frederick, MD USA Miller CJ Univ Calif Davis, CNPRC, 1 Shields Ave Davis, Davis, CA 95616 USA
    1. Year: 2003
  1. Journal: Journal of Medical Primatology
    1. 32
    2. 4-5
    3. Pages: 240-246
  2. Type of Article: Article
  1. Abstract:

    Inoculation of cats, goats and monkeys with plasmids encoding full-length proviral genomes results in persistent lentiviral infections. This system could be used as a method for administration of an attenuated human immunodeficiency virus (HIV) vaccine. Here, we compare the virology and immunology in rhesus macaques inoculated with either simian/human immunodeficiency virus 89.6 (SHIV 89.6) virus or a plasmid containing the SHIV 89.6 proviral genome. There was a delay in appearance of systemic infection in DNA-inoculated animals compared with virus-inoculated animals, but otherwise the pattern of infection was similar. The serum immunoglobulin G anti-simian immunodeficiency virus (SIV) binding antibody response in DNA-inoculated animals was also delayed compared with virus-inoculated animals, but ultimately there was no difference between live virus and DNA-inoculation in the ability to induce the anti-SIV immune responses that were measured. Thus, the data support the concept that plasmid DNA encoding an attenuated virus could be used instead live virus for vaccination.

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