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Immunoblastic lymphoma in persons with AIDS-associated Kaposi's sarcoma: A role for Kaposi's sarcoma-associated herpesvirus

  1. Author:
    Engels, E. A.
    Pittaluga, S.
    Whitby, D.
    Rabkin, C.
    Aoki, Y.
    Jaffe, E. S.
    Goedert, J. J.

  2. Author Address

    NCI, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS 8010, Bethesda, MD 20892 USA NCI, Ctr Canc Res, Expt Transplantat & Immunol Branch, Bethesda, MD 20892 USA NCI, Viral Epidemiol Sect, AIDS Vaccine Program, Frederick, MD 21701 USA NCI, Viral Epidemiol Branch, Div Canc & Epidemiol & Genet, Rockville, MD USA NCI, Hematopathol Sect, Pathol Lab, Canc Res Ctr, Rockville, MD USA Engels EA NCI, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS 8010, Bethesda, MD 20892 USA
    1. Year: 2003
  2. Journal: Modern Pathology
    1. 16
    2. 5
    3. Pages: 424-429
  4. Type of Article: Article
  1. Abstract:

    Kaposi's sarcoma-associated herpesvirus, the viral agent of Kaposi's sarcoma, is associated with two lymphoproliferative disorders: primary effusion lymphoma and multicentric Castleman's disease. To identify other lymphoproliferative conditions linked with Kaposi's sarcoma-associated herpesvirus, we studied non-Hodgkin's lymphomas arising in individuals with AIDS-associated Kaposi's sarcoma. Formalin-fixed tissues from 24 such lymphomas were examined. As expected, two primary effusion lymphomas were Kaposi's sarcoma-associated herpesvirus-positive, with immunohistochemistry demonstrating the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen in the nuclei of all neoplastic cells. Additionally, three of seven evaluable cases of the immunoblastic variant of diffuse large B-cell lymphoma (inummoblastic lymphoma) showed similar latency-associated nuclear antigen staining. These Kaposi's sarcoma-associated herpesvirus-positive inummoblastic lymphomas resembled primary effusion lymphoma histologically but were not known to involve body cavities (sites included lymph nodes, soft tissues of the neck, and spleen). Notably, 5-20% of the neoplastic cells in the Kaposi's sarcoma-associated herpesvirus-positive inummoblastic lymphomas also showed cytoplasmic staining for viral interleukin-6, a biologically active cytokine homologue found in primary effusion lymphoma. We conclude that Kaposi's sarcoma-associated herpesvirus is present in some inummoblastic lymphomas in persons with AIDS-associated Kaposi's sarcoma.

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