Skip NavigationSkip to Content
Return Return to Search Results

Effects of astragali radix on the growth of different cancer cell lines

  1. Author:
    Lin, J.
    Dong, H. F.
    Oppenheim, J. J.
    Howard, O. M.

  2. Author Address

    Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Gastroenterol, Shanghai 200021, Peoples R China Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Gastroenterol, Shanghai 200021, Peoples R China NCI, Mol Immunoregulat Lab, Frederick, MD 21702 USA Lin J Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Gastroenterol, Shanghai 200021, Peoples R China
    1. Year: 2003
  2. Journal: World Journal of Gastroenterology
    1. 9
    2. 4
    3. Pages: 670-673
  4. Type of Article: Article
  1. Abstract:

    AIM: To investigate the inhibitory effect of a Chinese herb medicine Astragali radix (AR) on growth of different cancer cell lines. METHODS: To observe the in vitro effects of AR on tumor cell proliferation by trypan blue exclusion, MTS method and tritium thymidine incorporation assay. Apoptosis was detected by DNA ladder method. RESULTS: The inhibition rates of AR on the cell respiration of AGS, KATOIII, HT29, MDA231, MEL7 and MEL14 were 68.25%, 62.36%, 22.8%, 27.69%, 2.85% and 5.14% respectively at the concentration of 100 ug/ml; it inhibited AGS DNA synthesis by 87.33% at the concentration of 50 ug/ml. The inhibitory effect on AGS was time-and dose-dependent. AR did not induce apoptosis in AGS cells. CONCLUSION: AR specifically inhibits gastric cancer cells growth in vitro and the mechanism is mainly cytostatic but not cytotoxic or inducing apoptosis.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel