Skip NavigationSkip to Content
Return Return to Search Results

The role of glycosphingolipids in HIV signaling, entry and pathogenesis

  1. Author:
    Viard, M.
    Parolini, I.
    Rawat, S. S.
    Fecchi, K.
    Sargiacomo, M.
    Puri, A.
    Blumenthal, R.

  2. Author Address

    Blumenthal, R, NCI Frederick, Lab Expt & Computat Biol, Ctr Canc Res, NIH, Frederick, MD 21701 USA NCI Frederick, Lab Expt & Computat Biol, Ctr Canc Res, NIH, Frederick, MD 21701 USA. Ist Super Sanita, I-00161 Rome, Italy.
    1. Year: 2003
  2. Journal: Glycoconjugate Journal
    1. 20
    2. 3
    3. Pages: 213-222
  4. Type of Article: Article
  1. Abstract:

    Although HIV uses CD4 and coreceptors (CCR5 and CXCR4) for productive infection of T cells, glycosphingolipids (GSL) may play ancillary roles in lymphoid and non-lymphoid cells. Interactions of the HIV Envelope Glycoprotein (Env) with GSL may help HIV in various steps of its pathogenesis. Physical-chemical aspects of the interactions between HIV Env and GSL leading to CD4-dependent entry into lymphocytes, the role of GSL in HIV transcytosis, and CD4-independent entry into non-lymphoid cells are reviewed. An overview of signaling properties of HIV receptors is provided with some speculation on how GSL may play a role in these events by virtue of being in membrane rafts. Finally, we summarize how interactions between HIV and coreceptors leading to signaling and/or fusion can be analyzed by the use of various tyrosine kinase and cytoskeletal inhibitors. Published in 2004

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel