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C to A single nucleotide polymorphism in intron 18 of the human MST1R (RON) gene that maps at 3p21.3

  1. Author:
    Angeloni, D.
    Duh, F. M.
    Moody, M.
    Dean, M.
    Zabarovsky, E. R.
    Sentchenko, V.
    Braga, E.
    Lerman, M. I.

  2. Author Address

    Scuola Superlore St Anna, Piazza Martiri Liberta,33, I-56100 Pisa, Italy NCI, Frederick Canc Res & Dev Ctr, Immunobiol Lab, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, SAIC, Intramural Res Support Program, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Lab Genom Divers, Frederick, MD 21702 USA Karolinska Inst, MTC, S-17177 Stockholm, Sweden Karolinska Inst, CGR, S-17177 Stockholm, Sweden Angeloni D Scuola Superlore St Anna, Piazza Martiri Liberta,33, I-56100 Pisa, Italy
    1. Year: 2003
    2. Date: APR-JUN
  2. Journal: Molecular and Cellular Probes
    1. 17
    2. 2-3
    3. Pages: 55-57
  4. Type of Article: Article
  1. Abstract:

    The MST1R (RON) gene, that maps at 3p21.3, encodes a protein tyrosine kinase receptor comprised of an extra-cellular domain that contains the ligand binding pocket and an intracellular region where the kinase domain is located. It controls cell survival and motility programs related to invasive growth. With the single strand conformation polymorphism (SSCP) method, a C to A nucleotide polymorphism (SNP) was found in intron 18 of the gene. The SNP has a frequency of 0.28 among African- American, 0.25 among Caucasian CEPH and 0.09 among Asian healthy individuals. During these studies, an alternatively spliced cDNA of MST1R, lacking exon 19, was also found that may result from this change. (C) 2003 Elsevier Science Ltd. All rights reserved.

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