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ERF, an ETS-related transcriptional repressor, can induce erythroid differentiation

  1. Author:
    Athanasiou, M.
    Blair, D. G.
    Mavrothalassitis, G.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, SAIC, Basic Res Program, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, SAIC, Basic Res Program, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, OMS, BRL,DBS,NCI,NIH, Frederick, MD 21702 USA FORTH, IMBB, GR-71110 Iraklion, Crete, Greece Med Univ Crete, GR-71110 Iraklion, Crete, Greece Athanasiou M NCI, Frederick Canc Res & Dev Ctr, SAIC, Basic Res Program, Frederick, MD 21702 USA
    1. Year: 2003
    2. Date: MAY-JUNE
  2. Journal: Anticancer Research
    1. 23
    2. 3A
    3. Pages: 2143-2153
  4. Type of Article: Article
  1. Abstract:

    Ets-family genes have been implicated in leukemia, as well as in normal hematopoiesis. ERF is an ets-related gene that represses transcription and is regulated by MAPK phosphorylation through its effect on ERF sub-cellular localization. Using pluripotent human cell lines, we studied the effect of ERF on erythroid differentiation. K562 and HEL cells expressing ERF expressed elevated levels of the etythroid-specific markers CD71 and Glycophorin A, as well as hemoglobin and GATA1. Treatment with the Erk kinase inhibitor PD98058 further enhanced the erythroid phenotype in ERF- expressing cells and cells expressing a non-phosphorylatable ERF mutant exhibited an even more enhanced phenontype. These results are consistent with the fact that ERF function is regulated by MAPK, and suggest that the effect of the MAPK pathway in erythroid differentiation is partially mediated by ERF. The effect of ERF is similar to the one shown for ETS1 and opposite to the FLI1 function in these cells, suggesting that several ets genes may play key roles in hematopoietic differentiation.

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