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The secret life of ACE2 as a receptor for the SARS virus

  1. Author:
    Dimitrov, D. S.

  2. Author Address

    NIH, NCI Frederick, CCR, LECB,Human Immunovirol & Computat Biol Grp, Ft Detrick, MD 21702 USA NIH, NCI Frederick, CCR, LECB,Human Immunovirol & Computat Biol Grp, Ft Detrick, MD 21702 USA Dimitrov DS NIH, NCI Frederick, CCR, LECB,Human Immunovirol & Computat Biol Grp, Ft Detrick, MD 21702 USA
    1. Year: 2003
  2. Journal: Cell
    1. 115
    2. 6
    3. Pages: 652-653
  4. Type of Article: Editorial Material
  1. Abstract:

    The membrane-associated carboxypeptidase angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function. Now, Li at al. identify and characterize an unexpected second function of ACE2 as a partner of the SARS-CoV spike glycoprotein in mediating virus entry and cell fusion.

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