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Seroincidence of human T-lymphotropic virus type I infection and characterization of seroconverters in Jamaican food handlers

  1. Author:
    Van Veldhuisen, P. C.
    Walters, M.
    Sawada, T.
    Levine, P. H.
    Wilks, R.
    Hanchard, B.
    Hisada, M.

  2. Author Address

    NCI, Div Canc Epidemiol & Genet, Viral Epidemiol Branch, 6120 Execut Blvd,EPS 8008, Rockville, MD 20852 USA NCI, Div Canc Epidemiol & Genet, Viral Epidemiol Branch, Rockville, MD 20852 USA George Washington Univ, Sch Publ Hlth & Hlth Serv, Washington, DC USA EMMES Corp, Rockville, MD USA NCI Frederick, Sci Applicat Int Corp, Viral Epidemiol Sect, Frederick, MD USA Eisai & Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 30026, Japan Univ W Indies, Res Inst Trop Med, Kingston 7, Jamaica Univ W Indies, Dept Pathol, Kingston 7, Jamaica Van Veldhuisen PC NCI, Div Canc Epidemiol & Genet, Viral Epidemiol Branch, 6120 Execut Blvd,EPS 8008, Rockville, MD 20852 USA
    1. Year: 2003
  2. Journal: Jaids-Journal of Acquired Immune Deficiency Syndromes
    1. 33
    2. 3
    3. Pages: 387-392
  4. Type of Article: Article
  1. Abstract:

    In a prospective study of food handlers in Jamaica, we estimated the age- and sex-specific seroincidence of human T- lymphotropic virus type I (HTLV-I) infection. Of 682 sexually active adults (132 males and 550 females) who were initially seronegative, 12 (1 male and 11 females) seroconverted over 8 years of follow-up. The seroincidence was 1.2 per 1,000 person- years for males and 3.2 per 1,000 person-years for females. The age-standardized incidence was 1.8 times higher for females than for males (P = 0.55). Within a median of 4 years after seroconversion, the median HTLV-I provirus load was 500 copies/10(5) cells, and the median antibody titer was 1:3109. Four of 12 seroconverters developed antibody to the Tax regulatory protein. HTLV-I infection in this population occurred at a rate comparable with that described for a Japanese cohort. Provirus load, titer and appearance of antibody to the Tax regulatory protein were typical of chronic carriers within a few years of seroconversion.

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