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Effects of Cd40 Stimulation in the Prevention of Human Ebv-Lymphomagenesis

  1. Author:
    Funakoshi, S.
    Taub, D. D.
    Asai, O.
    Hirano, A.
    Ruscetti, F. W.
    Longo, D. L.
    Murphy, W. J.

  2. Author Address

    Murphy WJ NCI FREDERICK CANC RES & DEV CTR SAIC BIOL CARCINOGENESIS & DEV PROGRAM BLDG 567 ROOM 141 FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR SAIC BIOL CARCINOGENESIS & DEV PROGRAM FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Leukemia & Lymphoma
    1. 24
    2. 3-4
    3. Pages: 187 ff.
  4. Type of Article: Review
  1. Abstract:

    CD40 is a molecule present on B lineage cells, both normal and neoplastic. Signalling through CD40 has been demonstrated to promote B cell growth and differentiation in vitro. In contrast to its effects on normal B cells, we have found that CD40 stimulation can inhibit the growth of various aggressive histology human B cell lymphomas both in vitro and in vivo. Moreover, using a human/mouse chimera model in which human EBV-induced B cell lymphomas can spontaneously arise, we have found that CD40 stimulation can prevent the occurrence of this human lymphoma in mice. However, normal human B cell engraftment and function was not adversely affected in these mice by CD40 stimulation. This indicates that CD40 stimulation is selective in its effects on aggressive histology B cell lymphomas. Thus, CD40 stimulation either by antibody or a recombinant soluble ligand, may be of potential clinical use, not only in the treatment of EBV-induced B cell lymphomas, but also in their prevention. [References: 32]

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