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Human neurodegenerative disease modeling using Drosophila

  1. Author:
    Bonini, N. M.
    Fortini, M. E.

  2. Author Address

    Univ Penn, Howard Hughes Med Inst, Dept Biol, 415 S Univ Ave, Philadelphia, PA 19104 USA Univ Penn, Howard Hughes Med Inst, Dept Biol, Philadelphia, PA 19104 USA NCI, Div Basic Sci, Ft Detrick, MD 21702 USA Bonini NM Univ Penn, Howard Hughes Med Inst, Dept Biol, 415 S Univ Ave, Philadelphia, PA 19104 USA
    1. Year: 2003
  2. Journal: Annual Review of Neuroscience
    1. 26
    2. Pages: 627-656
  4. Type of Article: Review
  1. Abstract:

    A number of approaches have been taken to recreate and to study the role of genes associated with human neurodegenerative diseases in the model organism Drosophila. These studies encompass the polyglutamine diseases, Parkinson's disease, Alzheimer's disease, and tau-associated pathologies. The findings highlight Drosophila as an important model system in which to study the fundamental pathways influenced by these genes and have led to new insights into aspects of pathogenesis and modifier mechanisms.

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