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Bcl-2 and P53 Immunophenotypes in Pre-Invasive, Early and Advanced Oesophageal Squamous Cancer

  1. Author:
    Parenti, A. R.
    Rugge, M.
    Shiao, Y. H.
    Ruol, A.
    Ancona, E.
    Bozzola, L.
    Ninfo, V.

  2. Author Address

    Rugge M UNIV PADUA DEPT PATHOL IST ANAT PATOL ULSS ALTA PADOVANA VIA A GABELLI 6 I-35121 PADUA ITALY UNIV PADUA DEPT PATHOL IST ANAT PATOL ULSS ALTA PADOVANA I-35121 PADUA ITALY NCI FREDERICK CANC RES & DEV CTR COMPARAT CARCINOGENESIS LAB DBS NIH FREDERICK, MD 21702 USA UNIV PADUA IST CHIRURG GEN 2 I-35100 PADUA ITALY OSPED VICENZA SERV ANAT PATOL VICENZA ITALY
    1. Year: 1997
  2. Journal: Histopathology
    1. 31
    2. 5
    3. Pages: 430-435
  4. Type of Article: Article
  1. Abstract:

    Aims: An inverse correlation between bcl-2 and p53 expression has been reported in several types of epithelial tumour. The role of bcl-2 and p53 in the development of oesophageal squamous carcinoma has yet to be established. The expression of bcl-2 and p53 proteins has been evaluated in the multistage oesophageal tumorigenesis, which progresses from normal mucosa to dysplasia (squamous intraepithelial lesion, SIL), to invasive early and advanced oesophageal squamous cancer, Methods and Results: Sixty-four cases of squamous oesophageal cancer, coexisting with SIL in IS cases, were immunohistochemically analysed for ang overexpression of bcl-2 and p53 proteins, Any association of bcl-2 and p53 protein expression with patient survival was also analysed. We observed bcl-2 expression that decreased significantly during the progression of oesophageal carcinogenesis, A decreasing frequency in the expression of bcl-2 in advanced oesophageal squamous cancer coincided with frequent p53 overexpression, bcl-2 expression was correlated with patient survival by univariate analysis, The association disappeared after adjusting for tumour stage, p53 overexpression showed no association with patient survival by either univariate or multivariate analysis. Conclusions: The down-regulation of bcl-2 and upregulation of p53 in advanced oesophageal squamous cancer suggest that bcl-2 and p53 proteins may interact in the progression of oesophageal squamous cancer. [References: 33]

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