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Recombinant antibodies for the diagnosis and treatment of cancer

  1. Author:
    Krauss, J.

  2. Author Address

    Natl Canc Inst, SAIC Frederick, Bldg 320,Rm 8, Frederick, MD 21702 USA Natl Canc Inst, SAIC Frederick, Frederick, MD 21702 USA Krauss J Natl Canc Inst, SAIC Frederick, Bldg 320,Rm 8, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Molecular Biotechnology
    1. 25
    2. 1
    3. Pages: 1-17
  4. Type of Article: Review
  1. Abstract:

    The advent of recombinant antibody technology led to an enormous revival in the use of antibodies as diagnostic and therapeutic tools for fighting cancer. This review provides a brief historical sketch of the development of recombinant antibodies for the diagnosis and immunotherapy of cancer and summarizes the most significant clinical data for the best established reagents to date. It also discusses clinically relevant aspects of the use of recombinant antibodies in cancer patients.

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