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Expression microdissection - Operator-independent retrieval of cells for molecular profiling

  1. Author:
    Tangrea, M. A.
    Chuaqui, R. F.
    Gillespie, J. W.
    Ahram, M.
    Gannot, G.
    Wallis, B. S.
    Best, C. J. M.
    Linehan, W. M.
    Liotta, L. A.
    Pohida, T. J.
    Bonner, R. F.
    Emmert-Buck, M. R.

  2. Author Address

    NCI, Pathogenet Unit, Pathol Lab, Canc Res Ctr, Bethesda, MD 20892 USA. NCI, Urol Oncol Branch, Canc Res Ctr, Bethesda, MD 20892 USA. Sci Applicat Intl Corp, Frederick, MD USA. Natl Canc Inst, Signal Proc & Instrumentat Sect, Computat Biosci & Engn Lab, Bethesda, MD USA. NICHHD, Lab Integrat & Med Biophys, Bethesda, MD 20892 USA Emmert-Buck, MR, NCI, Adv Technol Ctr, 8717 Grovemont Circle, Gaithersburg, MD 20878 USA
    1. Year: 2004
    2. Date: DEC
  2. Journal: Diagnostic Molecular Pathology
    1. 13
    2. 4
    3. Pages: 207-212
  4. Type of Article: Article
  1. Abstract:

    Tissue microdissection is an important method for the study of disease states. However, it is difficult to perform high-throughput molecular analysis with current techniques. We describe here a prototype version of a novel technique (expression microdissection) that allows for the procurement of desired cells via molecular targeting. Expression microdissection (xMD) offers significant advantages over available methods, including an increase in dissection speed of several orders of magnitude. xMD may become a valuable tool for investigators studying cancer or other disease states in patient specimens and animal models

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External Sources

  1. View record in Web of Science®
  2. WOS: 000225327900002

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