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Interleukin 2 plays a central role in Th2 differentiation

  1. Author:
    Cote-Sierra, J.
    Foucras, G.
    Guo, L. Y.
    Chiodetti, L.
    Young, H. A.
    Hu-Li, J.
    Zhu, J. F.
    Paul, W. E.

  2. Author Address

    Paul, WE, NIAID, Immunol Lab, NIH, Bldg 10,Room 11N311,10 Ctr Dr MSC 1892, Bethesda, MD 20892 USA NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA. NIAID, Cellular & Mol Immunol Lab, NIH, Bethesda, MD 20892 USA. NCI, Expt Immunol Lab, Ctr Canc Res, Frederick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 101
    2. 11
    3. Pages: 3880-3885
  4. Type of Article: Article
  1. Abstract:

    Differentiation of naive CD4T cells into T helper (Th)2 cells requires signaling through the T cell receptor and an appropriate cytokine environment. IL-4 is critical for such Th2 differentiation. We show that IL-2 plays a central role in this process. The effect of IL-2 on Th2 generation does not depend on its cell growth or survival effects. Stat5a(-/-) cells show diminished differentiation to IL-4 production, and forced expression of a constitutively active form of Stat5a replaces the need for IL-2. In vivo IL-2 neutralization inhibits IL-4 production in two models. Studies of restriction enzyme accessibility and binding of Stat5 to chromatin indicate that IL-2 mediates its effect by stabilizing the accessibility of the 1/4 gene. Thus, IL-2 plays a critical role in the polarization of naive CD4T cells to the Th2 phenotype

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