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Matrix Metalloproteinase-9 Maps to the Distal End of Chromosome 2 in the Mouse

  1. Author:
    Leco, K. J.
    Harvey, M. B.
    Hogan, A.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Edwards, D. R.
    Schultz, G. A.

  2. Author Address

    Schultz GA UNIV CALGARY DEPT MED BIOCHEM 3330 HOSP DR NW CALGARY AB T2N 4N1 CANADA UNIV CALGARY DEPT MED BIOCHEM CALGARY AB T2N 4N1 CANADA PRINCESS MARGARET HOSP ONTARIO CANC INST TORONTO ON M4X 1K9 CANADA QUEENSLAND UNIV TECHNOL SCH LIFE SCI BRISBANE QLD AUSTRALIA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM MAMMALIAN GENET LAB FREDERICK, MD 21701 USA
    1. Year: 1997
  2. Journal: Developmental Genetics
    1. 21
    2. 1
    3. Pages: 55-60
  4. Type of Article: Article
  1. Abstract:

    The activity and expression of matrix metalloproteinase-9/gelatinase B(MMP-9), an enzyme implicated in the implantation process in mice, was investigated in normal and parthenogenetic blastocyst outgrowths. Conditioned media from parthenogenetic blastocysts after 4 days of culture had reduced levels of MMP-9 activity compared to conditioned medium from normal outgrowths, levels of MMP-9 mRNA assayed by reverse transcription-polymerase chain reaction methods were also reduced in parthenogenetic blastocysts compared io normal outgrowths. Geneiic mapping studies showed that Mmp9 maps to the distal end of chromosome 2 near the proxima boundary of a region affected by genomic imprinting. Both parental alleles of Mmp9, however, are expressed in 11.5-day embryos derived from interspecific crosses of Mus musculus and Mus spretus. Thus, loss of MMP-9 activity in parthenogenetic blastocysts does not appear to be due to imprinting but, rather, due io a defect of trophoblast giant cell proliferation and differentiation. (C) 1997 Wiley-iiss, Inc. [References: 26]

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