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Structural basis of tyrosine sulfation and V-H-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

  1. Author:
    Huang, C. C.
    Venturi, M.
    Majeed, S.
    Moore, M. J.
    Phogat, S.
    Zhang, M. Y.
    Dimitrov, D. S.
    Hendrickson, W. A.
    Robinson, J.
    Sodroski, J.
    Wyatt, R.
    Choe, H.
    Farzan, M.
    Kwong, P. D.

  2. Author Address

    Kwong, PD, NIAID, Vaccine Res Ctr, NIH, 40 Convent Dr,Bldg 40,Room 4508, Bethesda, MD 20892 USA NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA. Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA. Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA. Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA. Harvard Univ, Childrens Hosp, Sch Med, Dept Pediat,Dept Med Microbiol & Mol Genet, Boston, MA 02115 USA. Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA. Harvard Univ, Sch Med, Dept Pathol, Div Aids, Boston, MA 02115 USA. NCI, NIH, Frederick, MD 21702 USA. Tulane Univ, Med Ctr, Dept Pediat, New Orleans, LA 70112 USA. Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA.
    1. Year: 2004
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 101
    2. 9
    3. Pages: 2706-2711
  4. Type of Article: Article
  1. Abstract:

    The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V-H-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition

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