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TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI)

  1. Author:
    Nanda, A.
    Carson-Walter, E. B.
    Seaman, S.
    Barber, T. D.
    Stampfl, J.
    Singh, S.
    Vogelstein, B.
    Kinzler, K. W.
    St Croix, B.

  2. Author Address

    St Croix, B, NCI, Mouse Canc Gneet Program, Tumor Angiogenesis Sect, Frederick, MD 21702 USA NCI, Mouse Canc Gneet Program, Tumor Angiogenesis Sect, Frederick, MD 21702 USA. Johns Hopkins Sch Med, Program Human Genet & Mol Biol, Baltimore, MD USA. Johns Hopkins Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA. Johns Hopkins Sch Med, Howard Hughes Med Inst, Baltimore, MD USA. Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15260 USA. Imgenex Corp, San Diego, CA USA.
    1. Year: 2004
  2. Journal: Cancer Research
    1. 64
    2. 3
    3. Pages: 817-820
  4. Type of Article: Article
  1. Abstract:

    Tumor endothelial marker (TEM)8 was uncovered as a gene expressed predominantly in tumor endothelium, and its protein product was recently identified as the receptor for anthrax toxin. Here, we demonstrate that TEM8 protein is preferentially expressed in endothelial cells of neoplastic tissue. We used the extracellular domain of TEM8 to search for ligands and identified the alpha3 subunit of collagen VI as an interacting partner. The TEM8-interacting region on collagen alpha3(VI) was mapped to its COOH-terminal C5 domain. Remarkably, collagen alpha3(VI) is also preferentially expressed in tumor endothelium in a pattern concordant with that of TEM8. These results suggest that the TEM8/C5 interaction may play an important biological role in tumor angiogenesis

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