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Enantioselective synthesis of metathesis-derived ureapeptoid macrocycles

  1. Author:
    Wang, X. Z.
    Burke, T. R.
  2. Author Address

    Burke, TR, NCI, Med Chem Lab, Ctr Canc Res, NIH, Frederick, MD 21701 USA NCI, Med Chem Lab, Ctr Canc Res, NIH, Frederick, MD 21701 USA.
    1. Year: 2004
  1. Journal: Synlett
    1. 3
    2. Pages: 469-472
  2. Type of Article: Article
  1. Abstract:

    Ring-closing metathesis (RCM) was used for the preparation of the first member of a new class of ureapeptoid-containing macrocycles. Key to the approach was the enantioselective synthesis of functionalized carbamoyl alkenylglycine equivalents using (-)-B-allyldiisopinocampheylborane [(-)-d-Ipc(2)Ball]-mediated asymmetric allylation

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