Skip NavigationSkip to Content
Return Return to Search Results

Familial clustering of classic Kaposi sarcoma

  1. Author:
    Guttman-Yassky, E.
    Cohen, A.
    Kra-Oz, Z.
    Friedman-Birnbaum, R.
    Sprecher, E.
    Zaltzman, N.
    Friedman, E.
    Silbermann, M.
    Rubin, D.
    Linn, S.
    Whitby, D.
    Gideoni, O.
    Pollack, S.
    Bergman, R.
    Sarid, R.

  2. Author Address

    Rambam Med Ctr, Dept Dermatol, Haifa, Israel. Rambam Med Ctr, Dept Virol, Haifa, Israel. Rambam Med Ctr, Dept Immunol, Haifa, Israel. Rambam Med Ctr, Epidemiol Unit, Haifa, Israel. Technion Israel Inst Technol, Bruce Rappaport Fac Med, Dept Cell Biol & Anat, IL-31096 Haifa, Israel. Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel. Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel. NCI, Viral Epidemiol Sect, AIDS Vaccine Program, Frederick, MD 21701 USA. Sarid, R, Bar Ilan Univ, Fac Life Sci, IL-52900 Ramat Gan, Israel
    1. Year: 2004
  2. Journal: Journal of Infectious Diseases
    1. 189
    2. 11
    3. Pages: 2023-2026
  4. Type of Article: Article
  1. Abstract:

    It is widely accepted that there is a causal association between Kaposi sarcoma-associated herpesvirus ( KSHV) and Kaposi sarcoma (KS). However, the majority of individuals infected with KSHV never develop KS. Here, we present a unique familial case of classic KS, in which the disease occurs in 4 siblings who have no recognized underlying immunodeficiency. We examine risk factors that could play a role in this condition, including KSHV infection, KSHV DNA load, genetic variants of KSHV, infection with additional viruses, interleukin-6-promoter polymorphism, and HLA genotype. We hypothesize that a genetic susceptibility to KS, in combination with KSHV infection, may play an important role in the presented familial case

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel