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Detection of Kaposi sarcoma-associated herpesvirus DNA in saliva and buffy-coat samples from children with sickle cell disease in Uganda

  1. Author:
    Mbulaiteye, S. M.
    Pfeiffer, R. M.
    Engels, E. A.
    Marshall, V.
    Bakaki, P. M.
    Owor, A. M.
    Ndugwa, C. M.
    Katongole-Mbidde, E.
    Goedert, J. J.
    Biggar, R. J.
    Whitby, D.

  2. Author Address

    NCI, Div Canc Epidemiol & Genet, US Dept HHS, Rockville, MD USA. Sci Applicat Corp Frederick, Viral Epidemiol Sect, AIDS Vaccine Program, NCI, Frederick, MD 21701 USA. Makerere Univ, Sch Med, Kampala, Uganda. Mulago Hosp, Kampala, Uganda Mbulaiteye, SM, 6120 Execut Blvd,Execut Plaza S,Room 8006, Rockville, MD 20852 USA
    1. Year: 2004
    2. Date: OCT 15
  2. Journal: Journal of Infectious Diseases
    1. 190
    2. 8
    3. Pages: 1382-1386
  4. Type of Article: Article
  1. Abstract:

    Among 233 children, Kaposi sarcoma-associated herpesvirus ( KSHV) DNA was detected in 43% of children seropositive for both K8.1 and orf73, in 29% of children seropositive for K8.1 only, in 14% of children seropositive for orf73 only, and in 7% of children seronegative for both K8.1 and orf73; among 228 mothers, KSHV DNA was detected in 27%, 25%, 4%, and 1%, respectively. KSHV DNA was detected more frequently and at higher levels in saliva than in buffy-coat samples and in children than in mothers. In both children and mothers, detection in saliva was associated with detection in peripheral blood. Detection was associated with K8.1 seropositivity, younger age, and high household density, indicating the importance of in-household person-to-person transmission, likely via saliva

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External Sources

  1. View record in Web of Science®
  2. WOS: 000223968700003

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