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Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5

  1. Author:
    Lederman, M. M.
    Veazey, R. S.
    Offord, R.
    Mosier, D. E.
    Dufour, J.
    Mefford, M.
    Piatak, M.
    Lifson, J. D.
    Salkowitz, J. R.
    Rodriguez, B.
    Blauvelt, A.
    Hartley, O.

  2. Author Address

    Case Western Reserve Univ, Univ Hosp, Dept Med, Cleveland, OH 44106 USA. Tulane Natl Primate Res Ctr, Covington, LA 70433 USA. Univ Geneva, Fac Med, Dept Struct Biol & Bioinformat, CH-1211 Geneva, Switzerland. Scripps Res Inst, La Jolla, CA 92037 USA. NCI, AIDS Vaccine Program, SAIC Frederick Inc, Frederick, MD 21702 USA. NCI, Dermatol Branch, Bethesda, MD 20892 USA Lederman, MM, Case Western Reserve Univ, Univ Hosp, Dept Med, 2061 Cornell Rd, Cleveland, OH 44106 USA
    1. Year: 2004
    2. Date: OCT 15
  2. Journal: Science
    1. 306
    2. 5695
    3. Pages: 485-487
  4. Type of Article: Article
  1. Abstract:

    Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus-modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention

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External Sources

  1. View record in Web of Science®
  2. WOS: 000224626500053

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