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Lack of associations between HLA class II alleles and resistance to HIV-1 infection among white, non-hispanic homosexual men

  1. Author:
    Liu, C. L.
    Carrington, M.
    Kaslow, R. A.
    Gao, X. J.
    Rinaldo, C. R.
    Jacobson, L. P.
    Margolick, J. B.
    Phair, J.
    Obrien, S. J.
    Detels, R.

  2. Author Address

    Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA. SAIC Frederick Inc, Basic Res Program, NCI, Frederick, MD USA. Univ Alabama, Sch Publ Hlth, Birmingham, AL 35294 USA. Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA. Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA. Northwestern Univ, Feinberg Sch Med, Howard Brown Hlth Ctr, Evanston, IL 60208 USA. NCI, Lab Genom Divers, Frederick, MD 21701 USA Detels, R, Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, 71-269 CHS,Box 951772, Los Angeles, CA 90095 USA
    1. Year: 2004
    2. Date: OCT 1
  2. Journal: Jaids-Journal of Acquired Immune Deficiency Syndromes
    1. 37
    2. 2
    3. Pages: 1313-1317
  4. Type of Article: Article
  1. Abstract:

    HLA class II alleles were molecularly typed for 100 high-risk seronegative men and 184 low-risk seroconverters from file Multicenter AIDS Cohort Study (MACS). Seven resistant individuals homozygous for CCR5 Delta32 deletions were excluded from analysis. In the Univariate analysis, no significant HLA class II associations with resistance/susceptibility to HIV type 1 infection were identified. However, the transporter associated with antigen presentation 2 (TAP2) Ala 665 variant associated with resistance in earlier analyses in the MACS was in linkage disequilibrium With some HLA class II alleles. After adjusting for the established associations with HLAA*0205 subgroup and TAP2 Ala 665 variant, no HLA class II alleles were independently associated with resistance/susceptibility to HIV-1 infection. Other genetic factors in the HLA class II-TAP region of the major histocorripatibility complex might be involved

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External Sources

  1. View record in Web of Science®
  2. WOS: 000224159300013

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