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A novel antimicrobial indolizinium alkaloid from Aniba panurensis

  1. Author:
    Klausmeyer, P.
    Chmurny, G. N.
    McCloud, T. G.
    Tucker, K. D.
    Shoemaker, R. H.

  2. Author Address

    SAIC Frederick Inc, Nat Prod Support Grp, Frederick, MD 21702 USA. SAIC Frederick Inc, Lab Proteom & Analyt Technol, Frederick, MD 21702 USA. SAIC Frederick Inc, Antimicrobial Res Support Grp, Frederick, MD 21702 USA. NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag, Frederick, MD 21702 USA McCloud, TG, SAIC Frederick Inc, Nat Prod Support Grp, Frederick, MD 21702 USA
    1. Year: 2004
    2. Date: OCT
  2. Journal: Journal of Natural Products
    1. 67
    2. 10
    3. Pages: 1732-1735
  4. Type of Article: Article
  1. Abstract:

    Activity-guided fractionation of an Aniba panurensis organic solvent extract has led to the isolation of the novel alkaloid 6,8-didec-(1Z)-enyl-5,7-dimethyl-2,3-dihydro-1H-indolizinium, as the trifluoroacetic acid salt (1). Its structure was determined by NMR and mass spectrometry. Bioassays performed in vitro demonstrated toxicity of compound 1 to a drug-resistant strain of Candida albicans

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External Sources

  1. View record in Web of Science®
  2. WOS: 000224707700020

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