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Hematotoxicity in workers exposed to low levels of benzene

  1. Author:
    Lan, Q.
    Zhang, L. P.
    Li, G. L.
    Vermeulen, R.
    Weinberg, R. S.
    Dosemeci, M.
    Rappaport, S. M.
    Shen, M.
    Alter, B. P.
    Wu, Y. J.
    Kopp, W.
    Waidyanatha, S.
    Rabkin, C.
    Guo, W. H.
    Chanock, S.
    Hayes, R. B.
    Linet, M.
    Kim, S.
    Yin, S. N.
    Rothman, N.
    Smith, M. T.

  2. Author Address

    Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA. NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Bethesda, MD 20892 USA. Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China. New York Blood Ctr, Clin Serv, White Plains, NY 10605 USA. Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC 27599 USA. Peking Union Med Coll, Beijing, Peoples R China. SAIC Frederick Inc, Frederick, MD 21702 USA. NCI, Ctr Canc Res, NIH, US Dept HHS, Bethesda, MD 20892 USA Smith, MT, Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA
    1. Year: 2004
    2. Date: DEC 3
  2. Journal: Science
    1. 306
    2. 5702
    3. Pages: 1774-1776
  4. Type of Article: Article
  1. Abstract:

    Benzene is known to have toxic effects on the blood and bone marrow, but its impact at levels below the U.S. occupational standard of 1 part per million (ppm) remains uncertain. in a study of 250 workers exposed to benzene, white blood cell and platelet counts were significantly lower than in 140 controls, even for exposure below 1 ppm in air. Progenitor cell colony formation significantly declined with increasing benzene exposure and was more sensitive to the effects of benzene than was the number of mature blood cells. Two genetic variants in key metabolizing enzymes, myeloperoxidase and NAD(P)H:quinone oxidoreductase, influenced susceptibility to benzene hematotoxicity. Thus, hematotoxicity from exposure to benzene occurred at air levels of 1 ppm or less and may be particularly evident among genetically susceptible subpopulations

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External Sources

  1. View record in Web of Science®
  2. WOS: 000225630800052

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