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Searching for the hereditary causes of renal-cell carcinoma

  1. Author:
    Pavlovich, C. P.
    Schmidt, L. S.

  2. Author Address

    Pavlovich, CP, Johns Hopkins Bayview Med Ctr, Brady Urol Inst, A-345,4940 Eastern Ave, Baltimore, MD 21224 USA Johns Hopkins Bayview Med Ctr, Brady Urol Inst, Baltimore, MD 21224 USA. NCI, Basic Res Program, SAIC Frederick Inc, Frederick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Nature Reviews Cancer
    1. 4
    2. 5
    3. Pages: 381-393
  4. Type of Article: Review
  1. Abstract:

    Families with hereditary predispositions to cancer continue to provide a unique opportunity for the identification and characterization of genes involved in carcinogenesis. A surprising number of genetic syndromes predispose to the development of renal-cell carcinoma, and already genes associated with five of these syndromes have been identified - VHL, MET, FH, BHD and HRPT2. These very different genes and the biochemical pathways in which they participate raise interesting questions about the development of renal cancers and could lead to new therapeutic approaches in the near future. So, what is known about hereditary renal cancer at present?

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