Skip NavigationSkip to Content
Return Return to Search Results

Chromatin remodeling by RNA polymerases

  1. Author:
    Studitsky, V. M.
    Walter, W.
    Kireeva, M.
    Kashlev, M.
    Felsenfeld, G.

  2. Author Address

    Studitsky, VM, Univ Med & Dent New Jersey, Dept Pharmacol, 675 Hoes Lane,Room 405, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey, Dept Pharmacol, Piscataway, NJ 08854 USA. Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA. NCI, Ctr Canc Res, Frederick Canc Res & Dev Ctr, Ft Detrick, MD 21702 USA. NIDDKD, Mol Biol Lab, NIH, Bethesda, MD 20892 USA.
    1. Year: 2004
  2. Journal: Trends in Biochemical Sciences
    1. 29
    2. 3
    3. Pages: 127-135
  4. Type of Article: Review
  1. Abstract:

    Chromatin packages DNA tightly into the eukaryotic nucleus and maintains its proper functioning. Recent studies suggest the existence of two distinct mechanisms of progression of RNA polymerases through chromatin. The first is characteristic of eukaryotic RNA polymerase III, bacteriophage RNA polymerases, and probably ATP-dependent chromatin remodeling complexes. In this mechanism, nucleosomes are translocated without release of the octamer into solution. By contrast, transcription by RNA polymerase II (Pol II) involves displacement of one H2A-H2B dimer. Nucleosomes can present a barrier for transcribing Pol II that can be regulated in vivo. Analysis of the mechanisms of transcription through chromatin should provide important information about mechanisms of chromatin remodeling and gene regulation at the level of transcript elongation

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel