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Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense

  1. Author:
    Yang, D.
    Biragyn, A.
    Hoover, D. M.
    Lubkowski, J.
    Oppenheim, J. J.

  2. Author Address

    Yang, D, NCI, Basic Res Program, Frederick, MD 21702 USA NCI, Basic Res Program, Frederick, MD 21702 USA. NCI, Macromol Crystallog Lab, SAIC, Frederick, MD 21702 USA. NCI, Mol Immunoregulat Lab, Ctr Canc Res, Frederick, MD 21702 USA. NIA, Immunol Lab, Gerontol Res Ctr, Bethesda, MD 20892 USA.
    1. Year: 2004
  2. Journal: Annual Review of Immunology
    1. 22
    2. Pages: 181-215
  4. Type of Article: Review
  1. Abstract:

    Mammals generate a diverse array of antimicrobial proteins, largely represented by defensins or cathelicidins. The direct in vitro microbicidal activity of antimicrobial proteins has long been considered an important innate immune defense, although the in vivo relevance has only very recently been established for certain defensins and cathelicidins. Mammalian defensins and cathelicidins have also been shown to have multiple receptor-mediated effects on immune cells. Beta-defensins interact with CCR6; murine beta-defensin-2 in addition activates TLR4. Cathelicidins act on FPRL1 -expressing cells. Furthermore, several defensins have considerable immunoenhancing activity. Thus, it appears that mammalian antimicrobial proteins contribute to both innate and adaptive antimicrobial immunity

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