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Sheathless electrospray ionization interfaces for capillary electrophoresis-mass spectrometric detection - Advantages and limitations

  1. Author:
    Issaq, H. J.
    Janini, G. M.
    Chan, K. C.
    Veenstra, T. D.

  2. Author Address

    NCI, SAIC Frederick Inc, Lab Proteom & Analyt Technol, Frederick, MD 20702 USA Issaq, HJ, NCI, SAIC Frederick Inc, Lab Proteom & Analyt Technol, POB B, Frederick, MD 20702 USA
    1. Year: 2004
    2. Date: OCT 22
  2. Journal: Journal of Chromatography A
    1. 1053
    2. 1-2
    3. Pages: 37-42
  4. Type of Article: Review
  1. Abstract:

    A review of sheathless interfaces for capillary electrophoresis (CE)-mass spectrometry (MS) is presented. The review discusses the on-line CE-MS system requirements, advantages and weaknesses of current sheathless interface designs for CE-electrospray ionization MS, and comparison between sheath flow and sheathless interfaces. The advantages and limitations of three sheathless designs are discussed and commented upon, these include single-capillary, two-capillary and three-piece designs. (C) 2004 Elsevier B.V. All rights reserved

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  2. DOI: 10.1016/j.chroma.2004.08.116
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