Skip NavigationSkip to Content
Return Return to Search Results

Endogenous leukemia inhibitory factor attenuates endotoxin response

  1. Author:
    Weber, M. A.
    Schnyder-Candrian, S.
    Schnyder, B.
    Quesniaux, V.
    Poli, V.
    Stewart, C. L.
    Ryffel, B.

  2. Author Address

    CNRS, F-45071 Orleans, France. NCI, Canc & Dev Biol Lab, FCRDC, Frederick, MD USA. Univ Turin, Dipartimento Genet Biol & Biochim, I-10124 Turin, Italy Ryffel, B, CNRS, 3B Rue Ferrollerie,GEM2358, F-45071 Orleans, France
    1. Year: 2005
    2. Date: FEB
  2. Journal: Laboratory Investigation
    1. 85
    2. 2
    3. Pages: 276-284
  4. Type of Article: Article
  1. Abstract:

    Leukemia inhibitory factor (LIF) is induced in inflammation and likely plays a regulatory role. Using LIF-deficient mice ( LIF -/-), we report here that endogenous LIF has a protective role in endotoxic shock and host defence. LIF -/- mice have heightened sensitivity to LPS in a LPS/D-galactosamine (D-Gal) sensitization model compared to wild-type mice ( LIF+/+), enhanced thrombocytopenia and leukopenia, with increased hepatic necrosis, neutrophil sequestration in the lung and accelerated mortality. These findings correlated with 10-fold higher tumour necrosis factor-alpha (TNFalpha) and interleukin-6 ( IL-6) serum levels and reduced IL-10 production in LIF -/- mice in response to LPS. Therefore, endogenous LIF attenuates the endotoxic shock response, enhances the expression of basal acute phase proteins and IL-10 production, which downregulates TNFalpha synthesis and release and thereby confers partial protection to endotoxemia

    See More

  1. Keywords:

External Sources

  1. View record in Web of Science®
  2. WOS: 000226719900014

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel