Skip NavigationSkip to Content
Return Return to Search Results

Umbelactonyl cinnamate derivatives from Crypteronia paniculata that mediate DNA strand scission

  1. Author:
    Deng, J. Z.
    Newman, D. J.
    Hecht, S. M.

  2. Author Address

    Hecht, SM, Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA Univ Virginia, Dept Chem, Charlottesville, VA 22901 USA. Univ Virginia, Dept Biol, Charlottesville, VA 22901 USA. Frederick Canc Res & Dev Ctr, Nat Prod Branch, Natl Canc Inst, Ft Detrick, MD 21702 USA.
    1. Year: 2005
  2. Journal: Journal of Natural Products
    1. 68
    2. 3
    3. Pages: 465-467
  4. Type of Article: Article
  1. Abstract:

    As part of an initiative to discover functional natural product analogues of bleomycin guided by the use of the COMPARE algorithm, a CH2Cl2-MeOH extract prepared from Crypteronia paniculata was found to exhibit relaxation of supercoiled pSP64 DNA in the presence of Cu2+. Bioassay-guided fractionation employing a DNA strand scission assay resulted in the isolation of three novel DNA cleavage agents. Their structures were elucidated as umbelactonyl cinnamate derivatives 1-3 through their NMR and MS spectral data analyses. This is the first example of the isolation and structural characterization of naturally occurring umbelactonyl cinnamate derivatives. Compound 1 exhibited strong Cu2+-dependent relaxation of supercoiled pSP64 DNA, while compounds 2 and 3 had only weak DNA cleavage activity

    See More

  1. Keywords:

External Sources

  1. View record in Web of Science®
  2. WOS: 000227927700037

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel