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Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines

  1. Author:
    Krakauer, T.
    Chen, X.
    Howard, O. M. Z.
    Young, H. A.

  2. Author Address

    USA, Med Res Inst Infect Dis, Dept Immunol & Mol Biol, Frederick, MD 21702 USA. NCI, SAIC Frederick, Basic Res Program, Frederick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Mol Immunoregulat Lab, Frederick, MD 21702 USA. Natl Canc Inst, Expt Immunol Lab, Canc Res Ctr, Frederick, MD USA Krakauer, T, USA, Med Res Inst Infect Dis, Dept Immunol & Mol Biol, Bldg 1425, Frederick, MD 21702 USA
    1. Year: 2005
  2. Journal: Immunopharmacology and Immunotoxicology
    1. 27
    2. 1
    3. Pages: 53-66
  4. Type of Article: Article
  1. Abstract:

    Proinflammatory cytokines mediate the toxic effects of superantigenic staphylococcal exotoxins (SE) and bacterial lipopolysaccharide (LPS). Triptolide, an oxygenated diterpene derived from a traditional Chinese medicinal herb, Tripterygium wilfordii, inhibited SE-stimulated T-cell proliferation (by 98%) and expression of interleukin 1 beta, interleukin 6, tumor necrosis factor, gamma interferon, monocyte chemotactic protein 1, macrophage inflammatory protein (MIP)-1 alpha, and MIP-1 beta by human peripheral blood mononuclear cells (PBMC). It also blocked the production of these cytokines and chemokines by LPS-stimulated PBMC in a dose-dependent manner. These results suggest that triptolide has potent immunosuppressive effects even counteracting the effects of superantigens and LPS. It also may be therapeutically useful for mitigating the pathogenic effects of these microbial products by downregulating the signaling pathways activated by both bacterial exotoxins and endotoxins

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  2. DOI: 10.1081/IPH-51294
  3. View record in Web of Science®
  4. WOS: 000227939800004

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