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Discoidin domain receptor 1 - A new class of receptor regulating leukocyte-collagen interaction

  1. Author:
    Yoshimura, T.
    Matsuyama, W.
    Kamohara, H.

  2. Author Address

    NCI, Ctr Canc Res, Lab Mol Immunoregulat, Frederick, MD 21702 USA Yoshimura, T, NCI, Ctr Canc Res, Lab Mol Immunoregulat, Bldg 599,Room 9, Frederick, MD 21702 USA
    1. Year: 2005
  2. Journal: Immunologic Research
    1. 31
    2. 3
    3. Pages: 219-229
  4. Type of Article: Article
  1. Abstract:

    Previous Studies demonstrated that type I collagen, a major component of the extracellular matrix, could influence the differentiation and function of leukocytes; however, it is not clear whether those effects of colla-en were based on its interaction with the classic collagen receptors, α 1β 1 and α 2β 1 integrins. We recently detected significant Upregulation of discoidin domain receptor 1 (DDR1), a new class of collagen receptor, in human leukocytes, including neutrophils, monocytes, and lymphocytes, in vitro, leading, to the hypothesis that the leukocyte-activating effects of collagen might be owing to its interaction with DDR1. In this review, we summarize Our recent findings demonstrating that DDR1-collagen interaction facilitates the adhesion, migration, differentiation/maturation, and cytokine/chemokine production of leukocytes. We also describe the intracellular signaling pathways activated by DDR1 interaction with collagen

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  1. View record in Web of Science®
  2. WOS: 000228982200005

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